Augusta University is involved in nearly 300 different funded research activities and related studies in its Colleges of Allied Health Sciences, Dental Medicine, Graduate Studies, Medicine and Nursing. Research is carried out in both basic and clinical disciplines.

Sub-communities within this community

Recent Submissions

  • CURS Connection May/June 2020

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-06)
    Table of Contents: Happy Birthday SSP!: CURS Summer Scholars Program Turns 10CURS: A Year in Pictures, Reflections by Undergraduate Researchers, Get Involved (Arsenal Undergraduate Research Journal, Seeking CURS Ambassadors, Undergrad Research Advising, and Faculty: Take your UR Mentorship in New Directions)
  • CURS Connection April 2020

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-04)
    Table of Contents: Congratulations to Dr. Sabbatini, Biological Sciences: 2020 CURS Mentor Excellence Award, Congratulations Summer Scholars Program Awardees!, Research Week Recap, Get Involved (Arsenal Undergraduate Research Journal and Undergrad Research Advising)
  • CURS Connection March 2020

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-03)
    Table of Contents: We're Still Here!, Congratulations Spring Grant Awardees!, Ayala Presents to Georgia Legislators, Take Note (Phi Kappa Phi (would have been) Presenters, Call for Nominations: Mentor Excellence Award), Get Involved (Summer Research Opportunities through NSF and Undergrad Research Advising)
  • CURS Connection February 2020

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-02)
    Table of Contents: Student Researcher Spotlight: Vinaya Alapatt, B.S., Meet the CURS Ambassadors, Upcoming Events, Student Resources (Upcoming Workshop: Oral and Poster Presentation Workshop, Undergrads: Publish Your Work!, Phi Kappa Phi Student Research and Fine Arts Conference, Summer Research Opportunities through NSF, Follow Us on Social Media, CURS Advising)
  • CURS Connection January 2020

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2020-01)
    Table of Contents: Congratulations Dr. Brandon Cromer and Dr. Laurence Miller!, Student Research Series: Rachel Hammesfahr, Senior, Biology major and Ananya Chakraborty, Senior, Cell and Molecular Biology Major, Upcoming Events, Faculty Resources (Call for Proposals and Research and Travel Grants), Student Resources (Apply to be a CURS 2020 Summer Scholar and Phi Kappa Phi Student Research and Fine Arts Conference), Summer Research Opportunities through NSF, Advising, Announcements (Follow on social media, chemical and lab safety training, The Arsenal is seeking submissions)
  • CURS Connection November/December 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-12)
    Table of Contents: Undergraduate Research Fair a Success, Student Research Series: Kyle Cartledge and Farron Aaronson, Mathematics and Isabella Santana, Cell and Molecular Biology, Georgia Undergraduate Research Conference (GURC), Faculty Resources (Faculty Information Sessions and Call for Summer Scholar Proposals), Student Resources (Vascular Biology Center Tour and High Five My Faculty: CURS Offering New Mentoring Award), Mark Your Calendars!, The 21st Annual Phi Kappa Phi Student Research & Fine Arts Conference.
  • CURS Connection October 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-10)
    Table of Contents: First Annual Undergraduate Research Fair, #Research News (Calling All Student Researchers and Chemical Safety Partners with CURS: Chemical and Lab Safety Training Comes to Summerville), Student Research Series: Nitish Sood and Anish Sangari, Cell and Molecular Biology, Leslie Duncan, Cell and Molecular Biology, Upcoming Events, Next Steps in Research Workshop, #ResearchNews (Calling Faculty Mentors, Art and Design Meet and Greet, and High Five My Faculty: CURS Offers a New Mentoring Award)
  • CURS Connection September 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-09)
    Table of Contents: Communications Student Involved in Multiple Scholarly Projects, High Five My Faculty: CURS Offers a New Mentoring Award, Student Research Series (Justin Brown, English major, Reeya Patel and Chandani Patel, Cell/Molecular Biology), Upcoming Events, #ResearchNews (Last Chance for 2019 GA Undergraduate Research Conference and Calling Faculty Mentors), #InTheKnow (Still Accepting Ambassadors! and Save the Date).
  • CURS Connection August 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-08)
    Table of Contents: Summer Scholars Symposium, Changes Coming in CURS Grant Opportunities, Student Research Series (Sabrina Nacci, English major, kicked off the Student Research Series (formerly known as Brown Bag), Upcoming Events, #ResearchNews (Call for Abstracts and CURS Ice Cream Social), Call for Nominations: CURS Ambassadors
  • CURS Connection June/July 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-07)
    Table of Contents: Summer Scholars Program Off to a Great Start, Fall Deadlines for Mini Grants, CURS in the Community, CURS Welcomes First Official Student Ambassador, Get Involved! (Undergraduate Research Portal (UROP) Helps Match Mentors and Students and HOW I INVESTIGATE: What does YOUR research time look like? Share it!).
  • CURS Connection May 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-05)
    Table of Contents: Ziembrowski Receives 2019 Mentor Excellence Award, University Scholars Program Students Present to SRNL Scientists, Summer Scholars Program Gets Underway, Undergrads Get a Closer Look at Cancer Research,
  • CURS Connection April 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-04)
    Table of Contents: AU Students Present Research to GA Legislators, Student Research Seminar: Deanna Doughty (Cellular & Molecular Biology major) and Michaela Mack (Mathematics major), Upcoming Events, #ResearchNews (Researcher Speaks with Undergraduates and Kinesiology Research Day), Congratulations!: CURS is pleased to announce our 2019 Summer Scholar students and faculty mentors!, Call for Nominations: CURS Ambassadors.
  • CURS Connection March 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-03)
    Table of Contents: Research Week is MARCH 11-15!, Mentor Highlights (Featured Mentor: Dr. Eric Numfor, Congratulations! Spring Grant Awards, Call for Nominations Mentor Excellence Award & CURS Ambassadors, Seeking CURS Ambassadors!), #ResearchNews (Chemical and Lab Safety Training (Health Sciences Campus), #JAGSWAG Stop by and grab a button!, 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference)
  • CURS Connection February 2019

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2019-02)
    Table of Contents: Message from the Director, Happenings at CURS (Arsenal: The Undergraduate Research Journal of Augusta University, Student Spotlight: Simran Mehrotra), What We Do: Undergraduate Research Opportunities Portal (UROP), Save the Date, This Month's Upcoming Events.
  • CURS Connection November 2018

    Center for Undergraduate Research and Scholarship; Davis, Quentin; Knapp, Melissa; Center for Undergraduate Research and Scholarship (Augusta University, 2018-11-26)
    Table of Contents: Don't miss the CURS Meet and Greet, Welcome Dr. Davis!! Check out our new Director of CURS, Chemical and Lab Safety Training, Opportunities to Present (33rd Annual NCUR, 8th Annual Lighting the Dream of Medicine Conference, Student Research Seminars)
  • Genomic Predictions in Uterine Cancers

    Tran, Lynn Kim Hoang; Center for Biotechnology and Genomic Medicine (Augusta University, 2020-05)
    Introduction: Current uterine cancer classification provides suboptimal treatment stratification and often groups together patients with significant differences in survival outcome and/or response. We used transcriptomic information to devise genomic scores for improved prediction of uterine cancer patient outcomes and validated these scores in our institutional cohorts. Project 1: In an early iteration of our gene signature discovery pipeline, we developed USC73, a genomic score for uterine serous carcinoma patients, which grouped patients into a low score (lower 66.7 percentile), good prognosis group and a high score (upper 33.3 percentile), poor prognosis group (5-year overall survival: 83.3% and 13.3%, respectively). USC73 predicts survival independently of stage, and can be combined with stage for further resolution of patient survival. Poor survivors have faster-growing tumors and lower rates of complete response to primary therapy. Project 2: We applied our pipeline to uterine endometrioid carcinoma, the most common histotype of uterine cancer, and developed UEC_IGS, an immune gene score that separates early stage patients into a high lymphocytic infiltration, good prognosis group (IGS 1) and a low lymphocytic infiltration, poor prognosis group (IGS 2). UEC_IGS predicts overall survival independent of grade and treatment. IGS 1 patients have higher levels of CD8+ tumor infiltrating lymphocytes (TILs), more CD45RO+/CD3+ memory T cells, and lower levels of FOXP3+ Tregs compared to IGS 2. Conclusion: Using transcriptomic data, we can reliably stratify uterine cancer patients into good and poor survival groups. This information can be used to facilitate recruitment of only poor prognosis patients into clinical trials, mitigating some heterogeneity in patient response and allowing clinicians to better identify treatments for patients who will not survive on the current therapy. Additionally, biological functions (e.g. cellular proliferation or immune infiltration) are associated with each genomic score, and these can serve as potential pathways to target for improving the outcome of poor survival groups.
  • Cell drinking: a closer look at how macropinocytosis drives cholesterol uptake in atherosclerotic vessels

    Lin, Huiping; Vascular Biology Center (Augusta University, 2020-05)
    Atherosclerotic vascular disease is the underlying cause of myocardial infarction, stable and unstable angina, stroke, peripheral artery disease and sudden cardiac death. Collectively, these cardiovascular diseases are responsible for the majority of deaths worldwide. Internalization of modified apolipoprotein B–containing lipoproteins by macrophages through scavenger receptor (SR)-mediated pathways is generally viewed as an essential step for the initiation and progression of atherosclerosis. Our studies were designed to investigate the contribution of receptor-independent LDL macropinocytosis to arterial lipid accumulation and atherosclerosis. We developed novel genetic and pharmacological approaches, utilized high resolution imaging techniques and employed unique in vivo lipid quantification assays to investigate the role of macrophage macropinocytosis in the pathogenesis of atherosclerosis. My results demonstrate that the macropinocytosis inhibitor EIPA and selective deletion of a key pathway regulating macropinocytosis in myeloid cells substantially decreased lesion size in both hypercholesterolemic wild type (WT) and SR knockout (CD36-/-/SR-A-/-) mice. Stimulation of macropinocytosis using genetic and physiologically relevant approaches promotes lipoprotein internalization by WT and CD36-/-/SR-A-/- macrophages, leading to foam cell formation. Serial section high-resolution imaging of murine and human atherosclerotic arteries identified for the first time subendothelial macrophages for the first time that demonstrate plasma membrane ruffling, cupping and macropinosome internalization. Immunoelectron microscopy, 3D reconstruction of macrophage foam cells and in vivo LDL tracking demonstrate macrophage internalization of LDL in human and murine atherosclerotic arteries via macropinocytosis. We next performed a large, unbiased-screen of an FDA-approved drug library to identify clinically relevant therapeutic agents that can be repurposed as pharmacological inhibitors of macropinocytosis. Our studies identified a low MW compound (imipramine) that inhibits macrophage macropinocytosis in vitro and in vivo. Imaging, toxicity and selectivity studies demonstrated that imipramine is a potent (IC50 = 130.9 nM), non-toxic (selectivity index CC50/IC50 > 300) and selective inhibitor of macropinocytosis. Repurposing of imipramine to inhibit macropinocytosis in hypercholesterolemic mice substantially decreased plaque development compared with control treatment. Taken together, our findings challenge the SR paradigm of atherosclerosis and identify inhibition of receptor-independent macrophage macropinocytosis as a new therapeutic strategy that may be beneficial in the treatment of atherosclerosis and its cardiovascular consequences.
  • The Gulf War Women’s Health Cohort: Study Design and Protocol

    Ansa, Benjamin E.; Sullivan, Kimberly; Krengel, Maxine H.; Heboyan, Vahé; Wilson, Candy; Lobst, Stacey; Coughlin, Steven S.; Institute of Public and Preventive Health (MDPI, 2020-04-02)
    Military service and deployment affect women differently than men, underscoring the need for studies of the health of women veterans and their receipt of health care services. Despite the large numbers of women who served during the 1990–1991 Gulf War, few studies have evaluated Gulf War illness (GWI) and other medical conditions specifically as they affect women veterans of the 1991 Gulf War. The objectives of the Gulf War Women’s Health Cohort study are: (1) to establish the Gulf War women’s cohort (GWWC), a large sample of women veterans who served in the 1990–1991 Gulf War and a comparison group of women who served in other locations during that period; and (2) to provide current, comprehensive data on the health status of women who served during the 1990–1991 Gulf War, and identify any specific conditions that affect Gulf War women veterans at excess rates. The study will utilize both existing datasets and newly collected data to examine the prevalence and patterns of Gulf War Illness symptoms, diagnosed medical conditions, reproductive health, birth outcomes and other health issues among women who served during the Gulf War. The Gulf War Women’s Health Cohort study will address the need for information about the comprehensive health of women veterans who were deployed to the Gulf War, and other wars during the Gulf War era.
  • APPLICATIONS OF MACHINE LEARNING TO GENOMICS: STUDIES IN TYPE 1 DIABETES AND CANCER

    Tran, Paul; Center for Biotechnology and Genomic Medicine (Augusta University, 2020-04)
    Introduction: A major aim of modern medicine is to translate basic genomics findings using machine learning and other data analysis methods into clinical tests for improving patient care. Herein, I applied machine learning methods to publicly available genetic and genomic data to address three clinical problems in cancer and type 1 diabetes (T1D) research. Project 1: Cancer classification mostly depends on the anatomic pathology workforce; hence, diagnosis is slow, stepwise, and prone to errors and systemic bias. Using a transcriptome-based cancer classification method, I reconciled the 18% disagreement rate between histology and mutation-based classifier for brain cancer. Project 2: I applied the same transcriptome-based classification method to lung adenocarcinoma and identified 3 novel subgroups comprising ~30% of lung adenocarcinoma. Project 3: The estimated genetic heritability of T1D is up to 80%. Identifying those most genetically susceptible to T1D can lead to reduction of the number of islet autoimmunity cases and the number diabetic ketoacidosis episodes. I developed a genetic risk prediction model using neural networks which performs better than currently published methods. I applied model interpretation methods to the neural network and identified important genetic drivers for characterizing T1D molecular subgroups. Conclusion: These projects are small steps in translating genomic medicine projects to clinical applications but represent a future with more objective and automated tools to aid in clinical decision making.
  • Clinical Guide for Intraosseous Pathology

    Malik, M; Kalathingal, S; Cullum, A; Buchanan, A; Abdelsayed, A; Kurago, Z; Department of Oral Biology & Diagnostic Sciences, Center for Instructional Innovation (Augusta University, 2019)
    To provide a reference database for dental students to describe and analyze intra osseous pathology that aid to develop a list of differential diagnoses for various diseases affecting the maxillofacial region on patients treated in student clinics. The online database will serve as a resource for descriptive terminology and samples to demonstrate the origin of the lesion, radiographic appearance, borders, contents, effects on adjacent structures, etc. which are the fundamental elements that guide a clinician in developing an impression and formulate the differential diagnosis. Histopathologic evaluation that provides the final diagnosis of each disease process will also be included to demonstrate that radiographic presentation of various disease categories may be similar, however, clinical management is ultimately decided by the tissue sample from the biopsy specimen. The interactive database will have various features that enable the user to access a comprehensive glossary list, word- defined searches, a brief overview of the most common diseases affecting dento-alveolar regions and learn about the management strategies.

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