Colleges & Programshttp://hdl.handle.net/10675.2/32024-03-08T08:18:20Z2024-03-08T08:18:20ZPlos One Transient Plasma Membrane Disruption Induced Calcium Waves in Mouse and Human Corneal Epithelial Cells - Figure Data FilesZhong, ChenLu, XiaowenWatsky, Mitchellhttp://hdl.handle.net/10675.2/6251192024-03-08T01:57:20ZPlos One Transient Plasma Membrane Disruption Induced Calcium Waves in Mouse and Human Corneal Epithelial Cells - Figure Data Files
Zhong, Chen; Lu, Xiaowen; Watsky, Mitchell
Data Files for figures 2-6 in manuscript titled "Transient Plasma Membrane Disruption Induced Calcium Waves in Mouse and Human Corneal Epithelial Cells" published in PLOS ONE.
The Effect of Adenosine in the Phenotype of Gingival FibroblastsSerrano-Lopez, Rogeliohttp://hdl.handle.net/10675.2/6249052023-11-21T06:07:04Z2023-08-01T00:00:00ZThe Effect of Adenosine in the Phenotype of Gingival Fibroblasts
Serrano-Lopez, Rogelio
Our research was focused on the role of gingival fibroblasts in the gingival inflammatory
response and in periodontitis. Previous work in our lab has identified adenosine signaling as a key
pathway able to control inflammatory chemokine secretion of gingival fibroblasts. The data from
human correlative studies comparing chemokine expression in healthy versus periodontitis was
combined with our in vitro analysis of immunofluorescence. Our in vitro data from
immunofluorescence results demonstrated the effect of adenosine in the inflammatory response of
gingival fibroblasts, typified by the expression of CXCL8- family of cytokines, including CXCL1.
We demonstrated the anti-inflammatory effect of adenosine on fibroblast phenotype typified by
the decreased IL-1β-stimulated CXCL1 expression.
CXCL1 was also significantly higher in samples derived from different grades/severity of
periodontitis compared to healthy-derived samples in our analysis of a public dataset. Our data
indicated fibroblasts have an important role in gingival inflammatory response. In our findings,
the expression or production of CXCL1 was abrogated after treating the human gingival
fibroblasts with adenosine after IL-1β stimulation. Thus, adenosine may influence the stromal
gingival inflammatory response in periodontitis by reducing the fibroblast-mediated activation of
inflammatory cells.
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2023-08-01T00:00:00ZEffects of Compression Garments on Oxygen Consumption and Heart RateGilbert, Haleyhttp://hdl.handle.net/10675.2/6249042023-11-21T06:06:56Z2023-08-01T00:00:00ZEffects of Compression Garments on Oxygen Consumption and Heart Rate
Gilbert, Haley
For my thesis I will be examining the influence full-leg compression garments have on oxygen
consumption and heart rate. It is speculated that compression garments assist with blood flow
velocity as well as increasing oxygen delivery to the muscles. It is well known that compression
garments aid in recovery and are widely used in the diabetic community to reduce pooling in the
lower limbs. What has not been well explored are the benefits to performance during running.
Studies show that compression garments reduce muscle oscillation, as well as soft tissue
movement (Bringard et al. 2006; Doan et al. 2003). It has been theorized this reduction creates
lower stress at the joints and a reduction in injury risk. It is reasonable to question that if
compression garments reduce muscle oscillation, then muscle activation time will also be
reduced because the muscles will not have to work as hard to counteract the additional
oscillating stress at impact. If muscles are not active for as long, then the muscles will not need
to produce as much energy or use as much oxygen. With an increase in blood flow and reduction
in muscle activation, the heart will not have to work as hard to circulate oxygen and similar
effects may occur for heart rate. However, very few studies have examined full-leg compression
garments while performing a submaximal endurance run. Therefore, we are testing subjects in
full-leg compression garments while performing a 40-minute submaximal effort run to determine
the effect on oxygen consumption and heart rate. From a runner's perspective I am intrigued with this topic because I am always looking for new
ways to enhance my performance during competition and compression garments could be that
next step. By gathering results from this research, it could potentially give us more information
on enhancing running performance. In the future we could expand on this research by looking at
more variables such as maximal oxygen uptake or examining the effects for longer endurance
runs like marathons.
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2023-08-01T00:00:00ZThe Effects of Quinolinic Acid on Muscles and BonesPatel, Rohanhttp://hdl.handle.net/10675.2/6249032023-11-09T02:10:25Z2023-07-29T00:00:00ZThe Effects of Quinolinic Acid on Muscles and Bones
Patel, Rohan
Quinolinic acid(QA) is an NMDA-receptor agonist associated with several neurological
illnesses, including Alzheimer's and Huntington's disease. QA is a metabolite of tryptophan
known for its excitotoxic nature in high concentrations. However, in normal conditions its acts as
a precursor in the manufacture of nicotinamide adenine dinucleotide (NAD+), a key molecule for
energy synthesis. As people age, the quantity of tryptophan and its metabolites, such as QA,
fluctuates. With age, QA levels rise, while tryptophan and NAD+ levels decline. QA’s known
association with energy production and beneficial properties is overlooked due to its toxic
behavior. In this study, we hope to further examine QA through a different perspective by
focusing on its potential healing properties rather than its harmful ones. We intend to investigate
QA by identifying its effects on muscles and bone marrow stem cells. To decipher its effects, in
vitro studies will be conducted. Through this process, we seek to learn if it has therapeutic
qualities through cell proliferation and whether it stimulates stem cell differentiation. In the end,
we believe that QA, a chemical with a negative connotation, will have notable healing effects on
bones and muscles and will be able to provide possible linkage with healthy aging.
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2023-07-29T00:00:00Z